Dispur College was established in 1978, with classes being held at Gopal Boro Govt. Higher Secondary School in the evening shift with arts faculty only. The founder principal was Sri Ghana Kanta Chetia Phukan. The college came into existence to meet the growing demand for higher education due to the shifting of the capital of Assam from Shillong to Dispur.
During the tenure of Principal Reba Kanta Hazarika the college shifted to its present premises in 1987, at the foothill of Narakasur Hill near Ganeshguri Chariali, Dispur, in the heart of Guwahati City. The night shift was discontinued and classes were converted to day shift. A morning shift was introduced to meet the demands of the students of the locality. From the academic session 1991-92 the commerce stream was introduced. Due to changing needs and demand for professional education, the college introduced BBA and BCA from the session 2007-08. The College also provides a platform for open learning via the K.K. Handique State open university.